Meriva (Thorne Curcumin Phytosome) has over 40 human clinical trials done to date that reflect both efficacy and safety. The company that produces Meriva is Indena, which is a nutraceutical and pharmaceutical company in Italy that has been in business since 1921: Indena | See through Science | Meriva®
Meriva Curcumin Phytosome has a safety profile that is superior, with long term human studies in complex situations showing benefits without side-effects. Not only does the product not stress the liver, which some curcumin products have been shown to do, it supports liver health. Additionally, it has been shown to benefit kidney health as well.
Let's look at one study from 2024:
This is a randomized controlled trial that was done for 72 weeks (16.5 months) in people with biopsy confirmed NASH (nonalcoholic steatohepatitis), 71% of whom had moderate liver scarring. Here is a summary of some of the results: 62% on Meriva had NASH resolution vs only 12% on placebo, 50% had chronic kidney disease regression vs 0% on placebo. Further, compared with placebo, fasting glucose improved 17 points, triglycerides reduced by 36 points, and HDL improved by 10 points.
Building off of that study, they discovered for the first time that a molecule called GLP2 produced in the intestinal lining, when suppressed, leads to chronic kidney disease in people with MASH: Impaired postprandial GLP-2 response enhances endotoxemia, systemic inflammation, and kidney injury in metabolic dysfunction-associated steatohepatitis (MASH): effect of phospholipid curcumin meriva - PubMed "Collectively, these data suggest that CKD may signal dysfunctional GLP-2 response to meals in MASH, with repetitive, meal-associated bouts of endotoxemia and pro-inflammatory NF-kB activation in MNCs potentially injuring the kidney." "Meriva treatment was associated with a significant increase in postprandial GLP-2 response, coupled with an improvement in postprandial intestinal permeability, endotoxemia and NF-kB activation in circulating MNCs (Table 1, Figure 1f–g)."
Dosage used in the study was 2 capsules 2X per day (1000mg 2X per day).
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